Medical DNA sequencing

The Medical Implications of Complete Mitochondrial DNA Sequencing

The mitochondrial DNA sequencing for the genealogical community until very recently was only of parts of the genome considered to be medically unimportant; however anyone can now have a test that will provide the complete mitochondrial DNA (mtDNA) sequence. But the results of this test may have medical implications; and in this article the factors showing this are discussed. The subjects of mit...

DNA Sequencing

Double stranded DNA sequencing as a choice for DNA sequencing.

Double stranded DNA sequencing (1) is favored because of its simplicity, and convenice. However it is only recently that the quality of this method has become comparable with single stranded DNA sequencing. We believe that two factors have limited the popularity of double stranded DNA sequencing: 1, the quality of the template DNA; 2, the inherent propertv.,of the DNA polymerase. The modified T...

DNA sequencing: clinical applications of new DNA sequencing technologies.

We are in a time of great change in genetics that may dramatically impact human biology and medicine. The completion of the human genome project,1,2 the development of low-cost, high-throughput parallel sequencing technology, and large-scale studies of genetic variation3 have provided a rich set of techniques and data for the study of genetic disease risk, treatment response, population diversi...

Dna Sequencing In

A DNA sequencing method has been developed whereby DNA that has been cloned in a single-stranded bacteriophage vector can be sequenced from both ends. The method involves f i r s t making a minus-strand sense template from a single-stranded insert in the vector MJ3mp2 using a flanking primer~ and then sequencing the synthesized template using the d i d e o x y n u c l e o t i d e termination me...